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All animals were housed under controlled temperature and a 12-hour lightdark cycle, with ad libitum access to food and water

If testing in animals and humans reveals 20uM is safe, dose escalation is possible since, according to Figure 3B , the niclosamide concentration can be increased to 30uM at pH 8.07 and 50uM is obtained at only pH 8.31

And you want to understand a bit about pro-oxidant properties and prooxidant effects

& Peskov, K

However, this work once again highlights the remarkable metabolic plasticity of tumour cellsa key aspect of cancer biologywhich allows them to adapt to adverse nutritional conditions and, in many cases, to develop therapy resistance